Semaglutide, its active ingredient, works by mimicking the activity of a naturally-occurring hormone in the body called GLP-1, which is released by your small intestine minutes after you eat. It binds to GLP-1 receptors in the body, causing the stomach to empty at a slower rate and also regulating the brain’s hunger signals. As a result, you feel fuller faster so you consume fewer calories. Compounded semaglutide is a prescription GLP-1 medication that may support healthy weight loss.