LDN

6mg/90 Bupropion 100mg (60 capsules) 

caps 90mg/6mg one month supply and 3 month supply 

LDN 6mg/bupropion 90-mg cap (60 caps )

modulates your immune system to suppress chronic inflammation and reduce oxidative stress –leading to improved immune function, reduced pain and fatigue, and enhanced quality of life.

It’s a combination of naltrexone, an opioid antagonist, and bupropion, an aminoketone antidepressant, indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of:

DOSAGE AND ADMINISTRATION

dose escalation schedule

Week 1 Week 2 Week 3 Week 4 – Onward

Morning Dose

1 tablet

1 tablet 2 tablets 2 tablets

Evening Dose

None 1 tablet 1 tablet 2 tablets

——————-DOSAGE FORMS AND STRENGTHS————————

Extended-Release Tablets: 8 mg naltrexone hydrochloride (HCl) /90 mg bupropion HCl (3)

Drug interactions 

MAOIs: Increased risk of hypertensive reactions can occur when used concomitantly. (7.1)

• Drugs Metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants, (e.g., selective serotonin reuptake inhibitors and many tricyclics), antipsychotics (e.g., haloperidol, risperidone and thioridazine), beta-blockers (e.g., metoprolol) and Type 1C antiarrhythmics (e.g., propafenone and flecainide): Consider dose reduction when using with CONTRAVE. (7.3)
• Digoxin: May decrease plasma digoxin levels. Monitor digoxin levels. (7.3)
• Concomitant Treatment with CYP2B6 Inhibitors (e.g., ticlopidine or clopidogrel) can increase bupropion exposure. Do not exceed one tablet twice daily when taken with CYP2B6 inhibitors. (2.5, 7.4)
• CYP2B6 Inducers (e.g., ritonavir, lopinavir, efavirenz, carbamazepine, phenobarbital, and phenytoin) may reduce efficacy by reducing bupropion exposure, avoid concomitant use. (7.4)
• Drugs that Lower Seizure Threshold: Dose CONTRAVE with caution. (5.3, 7.5)
• Dopaminergic Drugs (levodopa and amantadine): CNS toxicity can occur when used concomitantly with CONTRAVE. (7.6)
• Drug-Laboratory Test Interactions: CONTRAVE can cause false- positive urine test results for amphetamines. (7.8)Hormone optimization